Dataset Information

Organokines in COVID-19: A Systematic Review.

ABSTRACT: Coronavirus disease 2019 (COVID-19) is a viral infection caused by SARS-CoV-2 that induces a generalized inflammatory state. Organokines (adipokines, osteokines, myokines, hepatokines, and cardiokines) can produce beneficial or harmful effects in this condition. This study aimed to systematically review the role of organokines on COVID-19. PubMed, Embase, Google Scholar, and Cochrane databases were searched, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed, and 37 studies were selected, comprising more than 2700 individuals infected with the virus. Among COVID-19 patients, organokines have been associated with endothelial dysfunction and multiple organ failure due to augmented cytokines and increased SARS-CoV-2 viremia. Changes in the pattern of organokines secretion can directly or indirectly contribute to aggravating the infection, promoting immune response alterations, and predicting the disease progression. These molecules have the potential to be used as adjuvant biomarkers to predict the severity of the illness and severe outcomes.

SUBMITTER: Barbalho SM

PROVIDER: S-EPMC10216619 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Organokines in COVID-19: A Systematic Review.

Barbalho Sandra Maria SM Minniti Giulia G Miola Vitor Fernando Bordin VFB Haber Jesselina Francisco Dos Santos JFDS Bueno Patrícia Cincotto Dos Santos PCDS de Argollo Haber Luiza Santos LS Girio Raul S J RSJ Detregiachi Cláudia Rucco Penteado CRP Dall'Antonia Camila Tiveron CT Rodrigues Victória Dogani VD Nicolau Claudia C T CCT Catharin Virginia Maria Cavallari Strozze VMCS Araújo Adriano Cressoni AC Laurindo Lucas Fornari LF

Cells 20230509 10

Coronavirus disease 2019 (COVID-19) is a viral infection caused by SARS-CoV-2 that induces a generalized inflammatory state. Organokines (adipokines, osteokines, myokines, hepatokines, and cardiokines) can produce beneficial or harmful effects in this condition. This study aimed to systematically review the role of organokines on COVID-19. PubMed, Embase, Google Scholar, and Cochrane databases were searched, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelin ...[more]

PMID: 37408184

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Dataset Information

Organokines in COVID-19: A Systematic Review.

Publications

Organokines in COVID-19: A Systematic Review.

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