Accurate Detection of Urothelial Bladder Cancer Using Targeted Deep Sequencing of Urine DNA

ABSTRACT:

Simple Summary

Accurate, non-invasive methods that can diagnose bladder cancer (BC) are needed to detect BC in its early stages and reduce the burden on patients with hematuria. We developed uAL100, a method that accurately diagnoses BC by identifying tumor DNA in urine samples using targeted deep sequencing. We demonstrate that uAL100 accurately detects putative BC driver mutations in the urine without information about the tumor.

Abstract

Patients with hematuria are commonly given an invasive cystoscopy test to detect bladder cancer (BC). To avoid the risks associated with cystoscopy, several urine-based methods for BC detection have been developed, the most prominent of which is the deep sequencing of urine DNA. However, the current methods for urine-based BC detection

SUBMITTER: Lee D 

PROVIDER: S-EPMC10216686 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature