Preoperative Dose-Escalated Intensity-Modulated Radiotherapy (IMRT) and Intraoperative Radiation Therapy (IORT) in Patients with Retroperitoneal Soft-Tissue Sarcoma: Final Results of a Clinical Phase I/II Trial.

ABSTRACT:

Background

To report the final results of a prospective, one-armed, single-center phase I/II trial (NCT01566123).

Methods

Between 2007 and 2017, 37 patients with primary or recurrent (N = 6) retroperitoneal sarcomas were enrolled. Treatment included preoperative IMRT of 45-50 Gy with a simultaneous integrated boost of 50-56 Gy, surgery and IORT. The primary endpoint was local control (LC) at 5 years. The most common histology was dedifferentiated liposarcoma (51%), followed by leiomyosarcoma (24%) and well-differentiated liposarcoma (14%). The majority of lesions were high-grade (FNCLCC G1: 30%, G2: 38%, G3: 27%, two missing). Five patients were excluded from LC analysis per protocol.

Results

The minimum follow-up of the survivors was 62 months (median: 109; maximum 1

SUBMITTER: Seidensaal K 

PROVIDER: S-EPMC10216703 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature