Identification of Potential Inflammation-Related Genes and Key Pathways Associated with Complex Regional Pain Syndrome.

ABSTRACT: Complex regional pain syndrome (CRPS) is a chronic pain that affects the extremities after a trauma or nerve injury with no definite established treatment. The mechanisms mediating CRPS are not completely elucidated. Thus, we conducted a bioinformatics analysis to identify hub genes and key pathways to determine strategies for more effective treatments of CRPS. Finally, there is only one expression profile of GSE47063 in terms of homo sapiens-based CRPS from the Gene Expression Omnibus (GEO) database, which included four patients and five controls. We explored the differentially expressed genes (DEGs) in the dataset and conducted Gene Ontology (GO) functional and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of the potential hub genes. A protein-protein interaction (PP

SUBMITTER: Zhu H 

PROVIDER: S-EPMC10216790 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature