Evolution of the Immunoglobulin Isotypes-Variations of Biophysical Properties among Animal Classes.

ABSTRACT: The adaptive immune system arose around 500 million years ago in jawed fish, and, since then, it has mediated the immune defense against pathogens in all vertebrates. Antibodies play a central role in the immune reaction, recognizing and attacking external invaders. During the evolutionary process, several immunoglobulin isotypes emerged, each having a characteristic structural organization and dedicated function. In this work, we investigate the evolution of the immunoglobulin isotypes, in order to highlight the relevant features that were preserved over time and the parts that, instead, mutated. The residues that are coupled in the evolution process are often involved in intra- or interdomain interactions, meaning that they are fundamental to maintaining the immunoglobulin fold and to en

SUBMITTER: Pomarici ND 

PROVIDER: S-EPMC10216798 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature