LHX2 Is a Potential Biomarker and Associated with Immune Infiltration in Breast Cancer

ABSTRACT:

Simple Summary

Breast cancer is one of the most common malignant tumors in women, and metastatic breast cancer usually has a poor prognosis. Hence, it is urgent to identify new biomarkers to promote precise medication in breast cancer. LHX2 has been reported to promote the proliferation of numerous solid tumors, but its role in breast cancer has not been elucidated. Our study explored the prognostic value and the immune cell infiltration of breast cancer related to LHX2. We found that LHX2 can serve as an independent prognostic factor in breast cancer. In vitro and in vivo experiments confirmed that LHX2 promoted cell proliferation, migration ability, and invasive ability but inhibited apoptosis in breast cancer. Immunohistochemistry and immunofluorescence experiments were conduct

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PROVIDER: S-EPMC10216828 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature