The Significance of Hypothalamic Inflammation and Gliosis for the Pathogenesis of Obesity in Humans.

ABSTRACT: Accumulated preclinical literature demonstrates that hypothalamic inflammation and gliosis are underlying causal components of diet-induced obesity in rodent models. This review summarizes and synthesizes available translational data to better understand the applicability of preclinical findings to human obesity and its comorbidities. The published literature in humans includes histopathologic analyses performed postmortem and in vivo neuroimaging studies measuring indirect markers of hypothalamic tissue microstructure. Both support the presence of hypothalamic inflammation and gliosis in children and adults with obesity. Findings predominantly point to tissue changes in the region of the arcuate nucleus of the hypothalamus, although findings of altered tissue characteristics in whole hypo

SUBMITTER: Sewaybricker LE 

PROVIDER: S-EPMC10216879 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature