Feasibility of Renal Blood Flow Measurement Using ⁶⁴Cu-ATSM PET/MRI: A Quantitative PET and MRI Study.

ABSTRACT: This study aimed to evaluate the renal blood flow (RBF) in patients with chronic kidney disease (CKD) using ⁶⁴Cu(II)-diacetyl-bis(4-methylthiosemicarbazonate) (⁶⁴Cu-ATSM) for positron emission tomography (PET)/magnetic resonance imaging (MRI). We included five healthy controls (HCs) and ten patients with CKD. The estimated glomerular filtration rate (eGFR) was calculated from the serum creatinine (cr) and cystatin C (cys) levels. The estimated RBF (eRBF) was calculated using the eGFR, hematocrit, and filtration fraction. A single dose of ⁶⁴Cu-ATSM (300-400 MBq) was administered for RBF evaluation, and a 40 min dynamic PET scan was performed with simultaneous arterial spin labeling (ASL) imaging. PET-RBF images were obtained from the dynamic PET images at 3

SUBMITTER: Nishikawa Y 

PROVIDER: S-EPMC10216934 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature