O-GlcNAc Dynamics: The Sweet Side of Protein Trafficking Regulation in Mammalian Cells.

ABSTRACT: The transport of proteins between the different cellular compartments and the cell surface is governed by the secretory pathway. Alternatively, unconventional secretion pathways have been described in mammalian cells, especially through multivesicular bodies and exosomes. These highly sophisticated biological processes rely on a wide variety of signaling and regulatory proteins that act sequentially and in a well-orchestrated manner to ensure the proper delivery of cargoes to their final destination. By modifying numerous proteins involved in the regulation of vesicular trafficking, post-translational modifications (PTMs) participate in the tight regulation of cargo transport in response to extracellular stimuli such as nutrient availability and stress. Among the PTMs, O-GlcNAcylati

SUBMITTER: Ben Ahmed A 

PROVIDER: S-EPMC10216988 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature