Shifting from Left Ventricular Ejection Fraction to Strain Imaging in Aortic Stenosis.

ABSTRACT: Adverse ventricular remodeling is an inflexion point of disease progression in aortic stenosis (AS) and a major determinant of prognosis. Intervention before irreversible myocardial damage is of paramount importance to sustain favorable post-operative outcomes. Current guidelines recommend a left ventricular ejection fraction (LVEF)-based strategy to determine the threshold for intervention in AS. However, LVEF has several pitfalls: it denotes the left ventricular cavity volumetric changes and it is not suited to detecting subtle signs of myocardial damage. Strain has emerged as a contemporary imaging biomarker that describes intramyocardial contractile force, providing information on subclinical myocardial dysfunction due to fibrosis. A large body of evidence advocates its use to determin

SUBMITTER: Anastasiou V 

PROVIDER: S-EPMC10217605 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature