The NMDA receptor regulates integrin activation, ATP release and arterial thrombosis through store-operated Ca²⁺ entry in platelets.

ABSTRACT:

Introduction

Platelet activation and thrombus formation is crucial for hemostasis, but also trigger arterial thrombosis. Calcium mobilization plays an important role in platelet activation, because many cellular processes depend on the level of intracellular Ca²⁺ ([Ca²⁺](i)), such as integrin activation, degranulation, cytoskeletal reorganization. Different modulators of Ca²⁺ signaling have been implied, such as STIM1, Orai1, CyPA, SGK1, etc. Also, the N-methyl-D-aspartate receptor (NMDAR) was identified to contribute to Ca²⁺ signaling in platelets. However, the role of the NMDAR in thrombus formation is not well defined.

Methods

In vitro and in vivo analysis of platelet-specific NMDAR knock-out mice.

Results

I

SUBMITTER: Reusswig F 

PROVIDER: S-EPMC10217778 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature