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Neuroprotection of Andrographolide against Neurotoxin MPP⁺-Induced Apoptosis in SH-SY5Y Cells via Activating Mitophagy, Autophagy, and Antioxidant Activities.

ABSTRACT: Parkinson's disease (PD) is associated with dopaminergic neuron loss and alpha-synuclein aggregation caused by ROS overproduction, leading to mitochondrial dysfunction and autophagy impairment. Recently, andrographolide (Andro) has been extensively studied for various pharmacological properties, such as anti-diabetic, anti-cancer, anti-inflammatory, and anti-atherosclerosis. However, its potential neuroprotective effects on neurotoxin MPP⁺-induced SH-SY5Y cells, a cellular PD model, remain uninvestigated. In this study, we hypothesized that Andro has neuroprotective effects against MPP⁺-induced apoptosis, which may be mediated through the clearance of dysfunctional mitochondria by mitophagy and ROS by antioxidant activities. Herein, Andro pretreatment could attenuate

SUBMITTER: Prasertsuksri P

PROVIDER: S-EPMC10217882 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Neuroprotection of Andrographolide against Neurotoxin MPP⁺-Induced Apoptosis in SH-SY5Y Cells via Activating Mitophagy, Autophagy, and Antioxidant Activities.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Neuroprotection of Andrographolide against Neurotoxin MPP+-Induced Apoptosis in SH-SY5Y Cells via Activating Mitophagy, Autophagy, and Antioxidant Activities.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Neuroprotection of Andrographolide against Neurotoxin MPP⁺-Induced Apoptosis in SH-SY5Y Cells via Activating Mitophagy, Autophagy, and Antioxidant Activities.