Expression of Transposable Elements in the Brain of the Drosophila melanogaster Model for Fragile X Syndrome.

ABSTRACT: Fragile X syndrome is a neuro-developmental disease affecting intellectual abilities and social interactions. Drosophila melanogaster represents a consolidated model to study neuronal pathways underlying this syndrome, especially because the model recapitulates complex behavioural phenotypes. Drosophila Fragile X protein, or FMRP, is required for a normal neuronal structure and for correct synaptic differentiation in both the peripheral and central nervous systems, as well as for synaptic connectivity during development of the neuronal circuits. At the molecular level, FMRP has a crucial role in RNA homeostasis, including a role in transposon RNA regulation in the gonads of D. m. Transposons are repetitive sequences regulated at both the transcriptional and post-transc

SUBMITTER: De Donno MD 

PROVIDER: S-EPMC10218032 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature