Metabolomics Approach Reveals Important Glioblastoma Plasma Biomarkers for Tumor Biology.

ABSTRACT: Glioblastoma (GB) is the most aggressive and frequent primary malignant tumor of the central nervous system and is associated with poor overall survival even after treatment. To better understand tumor biochemical alterations and broaden the potential targets of GB, this study aimed to evaluate differential plasma biomarkers between GB patients and healthy individuals using metabolomics analysis. Plasma samples from both groups were analyzed via untargeted metabolomics using direct injection with an electrospray ionization source and an LTQ mass spectrometer. GB biomarkers were selected via Partial Least Squares Discriminant and Fold-Change analyses and were identified using tandem mass spectrometry with in silico fragmentation, consultation of metabolomics databases, and a literature sear

SUBMITTER: Ferrasi AC 

PROVIDER: S-EPMC10218163 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature