Unveiling CD59-Antibody Interactions to Design Paratope-Mimicking Peptides for Complement Modulation.

ABSTRACT: CD59 is an abundant immuno-regulatory human protein that protects cells from damage by inhibiting the complement system. CD59 inhibits the assembly of the Membrane Attack Complex (MAC), the bactericidal pore-forming toxin of the innate immune system. In addition, several pathogenic viruses, including HIV-1, escape complement-mediated virolysis by incorporating this complement inhibitor in their own viral envelope. This makes human pathogenic viruses, such as HIV-1, not neutralised by the complement in human fluids. CD59 is also overexpressed in several cancer cells to resist the complement attack. Consistent with its importance as a therapeutical target, CD59-targeting antibodies have been proven to be successful in hindering HIV-1 growth and counteracting the effect of complement inhibiti

SUBMITTER: Sandomenico A 

PROVIDER: S-EPMC10218266 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature