The Sts Proteins: Modulators of Host Immunity.

ABSTRACT: The suppressor of TCR signaling (Sts) proteins, Sts-1 and Sts-2, are a pair of closely related signaling molecules that belong to the histidine phosphatase (HP) family of enzymes by virtue of an evolutionarily conserved C-terminal phosphatase domain. HPs derive their name from a conserved histidine that is important for catalytic activity and the current evidence indicates that the Sts HP domain plays a critical functional role. Sts-1_HP has been shown to possess a readily measurable protein tyrosine phosphatase activity that regulates a number of important tyrosine-kinase-mediated signaling pathways. The in vitro catalytic activity of Sts-2_HP is significantly lower than that of Sts-1_HP, and its signaling role is less characterized. The highly conserved uniq

SUBMITTER: Zaman A 

PROVIDER: S-EPMC10218301 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature