Effects of Therapeutic Hypothermia on Macrophages in Mouse Cochlea Explants.

ABSTRACT: Globally, over the next few decades, more than 2.5 billion people will suffer from hearing impairment, including profound hearing loss, and millions could potentially benefit from a cochlea implant. To date, several studies have focused on tissue trauma caused by cochlea implantation. The direct immune reaction in the inner ear after an implantation has not been well studied. Recently, therapeutic hypothermia has been found to positively influence the inflammatory reaction caused by electrode insertion trauma. The present study aimed to evaluate the hypothermic effect on the structure, numbers, function and reactivity of macrophages and microglial cells. Therefore, the distribution and activated forms of macrophages in the cochlea were evaluated in an electrode insertion trauma cochlea cul

SUBMITTER: Bader W 

PROVIDER: S-EPMC10218374 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature