Three Major Causes of Metabolic Retinal Degenerations and Three Ways to Avoid Them.

ABSTRACT: An imbalance of homeostasis in the retina leads to neuron loss and this eventually results in a deterioration of vision. If the stress threshold is exceeded, different protective/survival mechanisms are activated. Numerous key molecular actors contribute to prevalent metabolically induced retinal diseases-the three major challenges are age-related alterations, diabetic retinopathy and glaucoma. These diseases have complex dysregulation of glucose-, lipid-, amino acid or purine metabolism. In this review, we summarize current knowledge on possible ways of preventing or circumventing retinal degeneration by available methods. We intend to provide a unified background, common prevention and treatment rationale for these disorders and identify the mechanisms through which these actions protect

SUBMITTER: Kovacs-Valasek A 

PROVIDER: S-EPMC10218427 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature