Comparative Transcriptomic Analysis of Three Common Liver Cell Lines.

ABSTRACT:

Background

Comparative transcriptomic analysis is a powerful approach for investigating the molecular mechanisms underlying various physiological and pathological processes, including liver disease. The liver is a vital organ with diverse functions, including metabolism and detoxification. In vitro models of liver cells, such as HepG2, Huh7, and Hep3B, have been widely used to study liver biology and pathology. However, there is limited information on the heterogeneity of these cell lines at the transcriptomic level.

Objective

This study aimed to conduct a comparative transcriptomic analysis of three common liver cell lines (HepG2, Huh7, and Hep3B) using publicly available RNA-sequencing data. In addition, we compared these cell lines to primary hepatocytes, cells isolated d

SUBMITTER: Arzumanian V 

PROVIDER: S-EPMC10218629 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature