The Role of Pharmacogenetics in Personalizing the Antidepressant and Anxiolytic Therapy.

ABSTRACT: Pharmacotherapy for neuropsychiatric disorders, such as anxiety and depression, has been characterized by significant inter-individual variability in drug response and the development of side effects. Pharmacogenetics, as a key part of personalized medicine, aims to optimize therapy according to a patient's individual genetic signature by targeting genetic variations involved in pharmacokinetic or pharmacodynamic processes. Pharmacokinetic variability refers to variations in a drug's absorption, distribution, metabolism, and elimination, whereas pharmacodynamic variability results from variable interactions of an active drug with its target molecules. Pharmacogenetic research on depression and anxiety has focused on genetic polymorphisms affecting metabolizing cytochrome P450 (CYP) and uri

SUBMITTER: Radosavljevic M 

PROVIDER: S-EPMC10218654 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature