Deletion of the foxO4 Gene Increases Hypoxia Tolerance in Zebrafish.

ABSTRACT: Oxygen homeostasis is an important organizing principle for understanding development, physiology, disease, and evolution. Under various physiological and pathological states, organisms experience oxygen deficiency or hypoxia. FoxO4 has been recognized as an important transcriptional regulator involved in a variety of cellular functions, including proliferation, apoptosis, differentiation, and stress resistance, but its role in hypoxia adaptation mechanisms in animals is not so clear. To explore the role of foxO4 in the hypoxia response, we detected the expression of foxO4 and the regulatory relationship between Hif1α and foxO4 under hypoxic conditions. It was found that the expression of foxO4 was up-regulated in ZF4 cells and zebrafish tissues after hypoxia tr

SUBMITTER: Shi L 

PROVIDER: S-EPMC10218838 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature