Functional Clustering of Metabolically Related Genes Is Conserved across Dikarya.

ABSTRACT: Transcriptional regulation is vital for organismal survival, with many layers and mechanisms collaborating to balance gene expression. One layer of this regulation is genome organization, specifically the clustering of functionally related, co-expressed genes along the chromosomes. Spatial organization allows for position effects to stabilize RNA expression and balance transcription, which can be advantageous for a number of reasons, including reductions in stochastic influences between the gene products. The organization of co-regulated gene families into functional clusters occurs extensively in Ascomycota fungi. However, this is less characterized within the related Basidiomycota fungi despite the many uses and applications for the species within this clade. This review wi

SUBMITTER: Cittadino GM 

PROVIDER: S-EPMC10218983 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature