Design, Synthesis, In Vitro Antifungal Activity and Mechanism Study of the Novel 4-Substituted Mandelic Acid Derivatives.

ABSTRACT: Plant diseases caused by phytopathogenic fungi are a serious threat in the process of crop production and cause large economic losses to global agriculture. To obtain high-antifungal-activity compounds with novel action mechanisms, a series of 4-substituted mandelic acid derivatives containing a 1,3,4-oxadiazole moiety were designed and synthesized. In vitro bioassay results revealed that some compounds exhibited excellent activity against the tested fungi. Among them, the EC₅₀ values of E₁₃ against Gibberella saubinetii (G. saubinetii), E₆ against Verticillium dahlia (V. dahlia), and E₁₈ against Sclerotinia sclerotiorum (S. sclerotiorum) were 20.4, 12.7, and 8.0 mg/L, respectively, w

SUBMITTER: Chen B 

PROVIDER: S-EPMC10219514 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature