Gene Expression Changes in Cytokine and Chemokine Receptors in Association with Melanoma Liver Metastasis.

ABSTRACT: Cytokines and chemokines (chemotactic cytokines) are soluble extracellular proteins that bind to specific receptors and play an integral role in the cell-to-cell signaling network. In addition, they can promote the homing of cancer cells into different organs. We investigated the potential relationship between human hepatic sinusoidal endothelial cells (HHSECs) and several melanoma cell lines for the expression of chemokine and cytokine ligands and receptor expression during the invasion of melanoma cells. In order to identify differences in gene expression related to invasion, we selected invasive and non-invasive subpopulations of cells after co-culturing with HHSECs and identified the gene expression patterns of 88 chemokine/cytokine receptors in all cell lines. Cell lines with stable i

SUBMITTER: Koroknai V 

PROVIDER: S-EPMC10219520 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature