Sesquiterpenes from the Fungus Antrodiella albocinnamomea with Cytotoxicity and Antibacterial Activity.

ABSTRACT: Eight new sesquiterpenes, namely, albocinnamins A-H (1-8), along with two known ones (9 and 10), have been isolated from the fungus Antrodiella albocinnamomea. Compound 1 possesses a new backbone that might be derived from cadinane-type sesquiterpene. Structures of the new compounds were elucidated by detailed spectroscopic data analysis, single-crystal X-ray diffraction, and ECD calculations. Compounds 1a and 1b showed cytotoxicity against SW480 and MCF-7 cells, with IC₅₀ values ranging from 19.3 to 33.3 μM, while compound 2 displayed cytotoxicity against the HL-60 cell with an IC₅₀ value of 12.3 μM. In addition, compounds 5 and 6 exhibited antibacterial activity against Staphylococcus au

SUBMITTER: Ning J 

PROVIDER: S-EPMC10219565 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature