Dopamine in the dorsal bed nucleus of stria terminalis signals Pavlovian sign-tracking and reward violations.

ABSTRACT: Midbrain and striatal dopamine signals have been extremely well characterized over the past several decades, yet novel dopamine signals and functions in reward learning and motivation continue to emerge. A similar characterization of real-time sub-second dopamine signals in areas outside of the striatum has been limited. Recent advances in fluorescent sensor technology and fiber photometry permit the measurement of dopamine binding correlates, which can divulge basic functions of dopamine signaling in non-striatal dopamine terminal regions, like the dorsal bed nucleus of the stria terminalis (dBNST). Here, we record GRAB_DA signals in the dBNST during a Pavlovian lever autoshaping task. We observe greater Pavlovian cue-evoked dBNST GRAB_DA signals in sign-tracking (ST)

SUBMITTER: Gyawali U 

PROVIDER: S-EPMC10219648 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature