Effectiveness of mRNA and inactivated COVID-19 vaccines: A test-negative study in an infection-naive Hong Kong population.

ABSTRACT:

Objective

Assess real-world effectiveness of vaccines against COVID-19.

Methods

A test-negative study was conducted in January-May 2022 during an Omicron BA.2 wave in Hong Kong. COVID-19 was identified by RT-PCR. 1-1 case-control matching was based on propensity score with vaccine effectiveness adjusted for confounders.

Results

Altogether, 1781 cases and 1737 controls aged 3-105 years were analysed. The mean lag time from the last dose of vaccination to testing for SARS-CoV-2 was 133.9 (SD: 84.4) days. Two doses of either vaccine within 180 days offered a low effectiveness against COVID-19 of all severity combined (VE_adj [95% CI] for BNT162b2: 27.0% [4.2-44.5], CoronaVac: 22.9% [1.3-39.7]), and further decreased after 180 days. Two doses of CoronaVac were p

SUBMITTER: Ng RWY 

PROVIDER: S-EPMC10219670 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature