Efficacy of flupirtine for postoperative pain: A systematic review and meta-analysis.

ABSTRACT:

Background and aims

Flupirtine has been used for various chronic pain conditions, but its utility in the perioperative period as an analgesic is still inconclusive. This systematic review and meta-analysis aimed to assess the efficacy of flupirtine for postoperative pain.

Methods

PubMed, Embase and the Cochrane Central Register of Controlled Trials (CENTRAL) were explored for the randomised controlled trials (RCTs) which compared flupirtine with other analgesic/placebo for perioperative pain in adult patients undergoing surgery. The standardised mean difference (SMD) of pain scores, the need for rescue analgesia and all adverse effects were assessed. Heterogeneity was assessed using Cochrane's Q statistic test and I² statistic. Cochrane Collaboration's tool was us

SUBMITTER: Dey S 

PROVIDER: S-EPMC10220165 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature