Disturbed insular functional connectivity and its clinical implication in patients with complex regional pain syndrome.

ABSTRACT:

Background

Complex regional pain syndrome (CRPS) is characterized by continued amplification of pain intensity. Given the pivotal roles of the insula in the perception and interpretation of pain, we examined insular functional connectivity and its associations with clinical characteristics in patients with CRPS.

Methods

Twenty-one patients with CRPS and 49 healthy controls underwent resting-state functional magnetic resonance imaging. The seed-to-seed functional connectivity analysis was performed for the bilateral insulae and cognitive control regions including the dorsal anterior cingulate cortex (dACC) and bilateral dorsolateral prefrontal cortex (DLPFC) between the two groups. Correlations between altered functional connectivity and clinical characteristics were assessed

SUBMITTER: Kim J 

PROVIDER: S-EPMC10220260 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature