Case Report: tacrolimus toxicity in the setting of concurrent Paxlovid use in a heart-transplant recipient

ABSTRACT: Abstract

Background

Tacrolimus toxicity in patient’s status post-orthotropic heart transplantation is not commonly reported. Given its narrow therapeutic window and drug–drug interactions, it must be closely monitored by providers who are experienced in transplant management. There are no case series of patients with tacrolimus toxicity in the setting of treatment for Sars-2-CoV-19 (COVID 19) for heart-transplant recipients. We present a case of tacrolimus toxicity in the setting of concurrent ritonavir–nirmatrelvir (Paxlovid) use.

Case summary

The patient was a 74-year-old male with a prior significant history of heart transplantation and on maintenance immunosuppression with tacrolimus. He contracted COVID-19 and was prescribed antiviral therapy with Paxlovid by an outs

SUBMITTER:  

PROVIDER: S-EPMC10220502 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature