Membrane Order Effect on the Photoresponse of an Organic Transducer.

ABSTRACT: Non-genetic photostimulation, which allows for control over cellular activity via the use of cell-targeting phototransducers, is widely used nowadays to study and modulate/restore biological functions. This approach relies on non-covalent interactions between the phototransducer and the cell membrane, thus implying that cell conditions and membrane status can dictate the effectiveness of the method. For instance, although immortalized cell lines are traditionally used in photostimulation experiments, it has been demonstrated that the number of passages they undergo is correlated to the worsening of cell conditions. In principle, this could impact cell responsivity against exogenous stressors, including photostimulation. However, these aspects have usually been neglected in previous experim

SUBMITTER: Vurro V 

PROVIDER: S-EPMC10220526 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature