Germanium Dioxide Nanoparticles Mitigate Biochemical and Molecular Changes Characterizing Alzheimer's Disease in Rats.

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disorder that jeopardizes the lives of diagnosed patients at late stages. This study aimed to assess, for the first time, the efficiency of germanium dioxide nanoparticles (GeO₂NPs) in mitigating AD at the in vivo level compared to cerium dioxide nanoparticles (CeO₂NPs). Nanoparticles were synthesized using the co-precipitation method. Their antioxidant activity was tested. For the bio-assessment, rats were randomly assigned into four groups: AD + GeO₂NPs, AD + CeO₂NPs, AD, and control. Serum and brain tau protein, phosphorylated tau, neurogranin, amyloid β peptide 1-42, acetylcholinesterase, and monoamine oxidase levels were measured. Brain histopathological evaluation was conducted. Furthermore, n

SUBMITTER: Abdel Gaber SA 

PROVIDER: S-EPMC10220875 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature