Functional Profiling of the A-Family of Venom Peptides from the Wolf Spider Lycosa shansia.

ABSTRACT: The venoms of spiders from the RTA (retro-lateral tibia apophysis) clade contain diverse short linear peptides (SLPs) that offer a rich source of therapeutic candidates. Many of these peptides have insecticidal, antimicrobial and/or cytolytic activities, but their biological functions are unclear. Here, we explore the bioactivity of all known members of the A-family of SLPs previously identified in the venom of the Chinese wolf spider (Lycosa shansia). Our broad approach included an in silico analysis of physicochemical properties and bioactivity profiling for cytotoxic, antiviral, insecticidal and antibacterial activities. We found that most members of the A-family can form α-helices and resemble the antibacterial peptides found in frog poison. The peptides we tested showed no cyto

SUBMITTER: Luddecke T 

PROVIDER: S-EPMC10221074 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature