Sympathetic Modulation in Cardiac Arrhythmias: Where We Stand and Where We Go.

ABSTRACT: The nuance of autonomic cardiac control has been studied for more than 400 years, yet little is understood. This review aimed to provide a comprehensive overview of the current understanding, clinical implications, and ongoing studies of cardiac sympathetic modulation and its anti-ventricular arrhythmias' therapeutic potential. Molecular-level studies and clinical studies were reviewed to elucidate the gaps in knowledge and the possible future directions for these strategies to be translated into the clinical setting. Imbalanced sympathoexcitation and parasympathetic withdrawal destabilize cardiac electrophysiology and confer the development of ventricular arrhythmias. Therefore, the current strategy for rebalancing the autonomic system includes attenuating sympathoexcitation and increasin

SUBMITTER: Chung WH 

PROVIDER: S-EPMC10221179 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature