Highly Stable Docetaxel-Loaded Nanoparticles Based on Poly(D,L-lactide)-b-Poly(ethylene glycol) for Cancer Treatment: Preparation, Characterization, and In Vitro Cytotoxicity Studies.

ABSTRACT: Stability and narrow size distribution are among the main requirements that apply to drug formulations based on polymeric nanoparticles. In this study, we obtained a series of particles based on biodegradable poly(D,L-lactide)-b-poly(ethylene glycol) (P(D,L)LA_n-b-PEG₁₁₃) copolymers with varied hydrophobic P(D,L)LA block length n from 50 to 1230 monomer units stabilized by poly(vinyl alcohol) (PVA) by a simple "oil-in-water" emulsion method. We found that nanoparticles of P(D,L)LA_n-b-PEG₁₁₃ copolymers with relatively short P(D,L)LA block (n ≤ 180) are prone to aggregate in water. P(D,L)LA_n-b-PEG₁₁₃ copolymers with n ≥ 680 can form spherical unimodal particles with values of hyd

SUBMITTER: Kuznetsova EV 

PROVIDER: S-EPMC10221316 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature