Repurposing of Doramectin as a New Anti-Zika Virus Agent.

ABSTRACT: Zika virus (ZIKV), belonging to the Flavivirus family and mainly transmitted by mosquitoes, causes a variety of adverse outcomes, including Guillain-Barré syndrome, microcephaly, and meningoencephalitis. However, there are no approved vaccines or drugs available for ZIKV. The discovery and research on drugs for ZIKV are still essential. In this study, we identified doramectin, an approved veterinary antiparasitic drug, as a novel anti-ZIKV agent (EC₅₀ value from 0.85 μM to 3.00 μM) with low cytotoxicity (CC₅₀ > 50 μM) in multiple cellular models. The expression of ZIKV proteins also decreased significantly under the treatment of doramectin. Further study showed that doramectin directly interacted with the key enzyme for ZIKV genome replication, RNA-dependent RN

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10221537 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature