Phase-Amplitude Coupling Localizes Pathologic Brain with Aid of Behavioral Staging in Sleep.

ABSTRACT: Low frequency brain rhythms facilitate communication across large spatial regions in the brain and high frequency rhythms are thought to signify local processing among nearby assemblies. A heavily investigated mode by which these low frequency and high frequency phenomenon interact is phase-amplitude coupling (PAC). This phenomenon has recently shown promise as a novel electrophysiologic biomarker, in a number of neurologic diseases including human epilepsy. In 17 medically refractory epilepsy patients undergoing phase-2 monitoring for the evaluation of surgical resection and in whom temporal depth electrodes were implanted, we investigated the electrophysiologic relationships of PAC in epileptogenic (seizure onset zone or SOZ) and non-epileptogenic tissue (non-SOZ). That this biomarker ca

SUBMITTER: Berry B 

PROVIDER: S-EPMC10221792 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature