Chemomodulatory Effect of the Marine-Derived Metabolite "Terrein" on the Anticancer Properties of Gemcitabine in Colorectal Cancer Cells.

ABSTRACT:

Background

Terrein (Terr) is a bioactive marine secondary metabolite that possesses antiproliferative/cytotoxic properties by interrupting various molecular pathways. Gemcitabine (GCB) is an anticancer drug used to treat several types of tumors such as colorectal cancer; however, it suffers from tumor cell resistance, and therefore, treatment failure.

Methods

The potential anticancer properties of terrein, its antiproliferative effects, and its chemomodulatory effects on GCB were assessed against various colorectal cancer cell lines (HCT-116, HT-29, and SW620) under normoxic and hypoxic (pO₂ ≤ 1%) conditions. Further analysis via flow cytometry was carried out in addition to quantitative gene expression and ¹HNMR metabolomic analysis.

Results

In

SUBMITTER: Abuhijjleh RK 

PROVIDER: S-EPMC10221861 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature