Surface Functionalised Parenteral Nanoemulsions for Active and Homotypic Targeting to Melanoma.

ABSTRACT: Despite recent progressions in cancer genomic and immunotherapies, advanced melanoma still represents a life threat, pushing to optimise new targeted nanotechnology approaches for specific drug delivery to the tumour. To this aim, owing to their biocompatibility and favourable technological features, injectable lipid nanoemulsions were functionalised with proteins owing to two alternative approaches: transferrin was chemically grafted for active targeting, while cancer cell membrane fragments wrapping was used for homotypic targeting. In both cases, protein functionalisation was successfully achieved. Targeting efficiency was preliminarily evaluated using flow cytometry internalisation studies in two-dimensional cellular models, after fluorescence labelling of formulations with 6-coumarin.

SUBMITTER: Foglietta F 

PROVIDER: S-EPMC10222029 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature