Functional Profiling and Evolutionary Analysis of a Marine Microalgal Virus Pangenome.

ABSTRACT: Phycodnaviridae are large double-stranded DNA viruses, which facilitate studies of host-virus interactions and co-evolution due to their prominence in algal infection and their role in the life cycle of algal blooms. However, the genomic interpretation of these viruses is hampered by a lack of functional information, stemming from the surprising number of hypothetical genes of unknown function. It is also unclear how many of these genes are widely shared within the clade. Using one of the most extensively characterized genera, Coccolithovirus, as a case study, we combined pangenome analysis, multiple functional annotation tools, AlphaFold structural modeling, and literature analysis to compare the core and accessory pangenome and assess support for novel functional predictions. We determin

SUBMITTER: Lobb B 

PROVIDER: S-EPMC10222054 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature