Ontology highlight
ABSTRACT:
SUBMITTER: Kang B
PROVIDER: S-EPMC10222209 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Kang Borui B Mottamal Madhusoodanan M Zhong Qiu Q Bratton Melyssa M Zhang Changde C Guo Shanchun S Hossain Ahamed A Ma Peng P Zhang Qiang Q Wang Guangdi G Payton-Stewart Florastina F
Pharmaceuticals (Basel, Switzerland) 20230512 5
Niclosamide effectively downregulates androgen receptor variants (AR-Vs) for treating enzalutamide and abiraterone-resistant prostate cancer. However, the poor pharmaceutical properties of niclosamide due to its solubility and metabolic instability have limited its clinical utility as a systemic treatment for cancer. A novel series of niclosamide analogs was prepared to systematically explore the structure-activity relationship and identify active AR-Vs inhibitors with improved pharmaceutical pr ...[more]