Gene Therapy Using Efficient Direct Lineage Reprogramming Technology for Neurological Diseases.

ABSTRACT: Gene therapy is an innovative approach in the field of regenerative medicine. This therapy entails the transfer of genetic material into a patient's cells to treat diseases. In particular, gene therapy for neurological diseases has recently achieved significant progress, with numerous studies investigating the use of adeno-associated viruses for the targeted delivery of therapeutic genetic fragments. This approach has potential applications for treating incurable diseases, including paralysis and motor impairment caused by spinal cord injury and Parkinson's disease, and it is characterized by dopaminergic neuron degeneration. Recently, several studies have explored the potential of direct lineage reprogramming (DLR) for treating incurable diseases, and highlighted the advantages of DLR ove

SUBMITTER: Chang Y 

PROVIDER: S-EPMC10222404 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature