Long-Term Soft-Food Rearing in Young Mice Alters Brain Function and Mood-Related Behavior.

ABSTRACT: The relationship between caloric and nutrient intake and overall health has been extensively studied. However, little research has focused on the impact of the hardness of staple foods on health. In this study, we investigated the effects of a soft diet on brain function and behavior in mice from an early age. Mice fed a soft diet for six months exhibited increased body weight and total cholesterol levels, along with impaired cognitive and motor function, heightened nocturnal activity, and increased aggression. Interestingly, when these mice were switched back to a solid diet for three months, their weight gain ceased, total cholesterol levels stabilized, cognitive function improved, and aggression decreased, while their nocturnal activity remained high. These findings suggest that long-te

SUBMITTER: Furukawa M 

PROVIDER: S-EPMC10222696 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature