Unravelling Novel Phytochemicals and Anticholinesterase Activity in Irish Cladonia portentosa.

ABSTRACT: Acetylcholinesterase inhibitors remain the mainstay of symptomatic treatment for Alzheimer's disease. The natural world is rich in acetylcholinesterase inhibitory molecules, and research efforts to identify novel leads is ongoing. Cladonia portentosa, commonly known as reindeer lichen, is an abundant lichen species found in Irish Boglands. The methanol extract of Irish C. portentosa was identified as an acetylcholinesterase inhibitory lead using qualitative TLC-bioautography in a screening program. To identify the active components, the extract was deconvoluted using a successive extraction process with hexane, ethyl acetate and methanol to isolate the active fraction. The hexane extract demonstrated the highest inhibitory activity and was selected for further phytochemical i

SUBMITTER: Nagar S 

PROVIDER: S-EPMC10222842 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature