Engineered Phage-Based Cancer Vaccines: Current Advances and Future Directions.

ABSTRACT: Bacteriophages have emerged as versatile tools in the field of bioengineering, with enormous potential in tissue engineering, vaccine development, and immunotherapy. The genetic makeup of phages can be harnessed for the development of novel DNA vaccines and antigen display systems, as they can provide a highly organized and repetitive presentation of antigens to immune cells. Bacteriophages have opened new possibilities for the targeting of specific molecular determinants of cancer cells. Phages can be used as anticancer agents and carriers of imaging molecules and therapeutics. In this review, we explored the role of bacteriophages and bacteriophage engineering in targeted cancer therapy. The question of how the engineered bacteriophages can interact with the biological and immunological

SUBMITTER: Ragothaman M 

PROVIDER: S-EPMC10222954 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature