Biological Activity of Naphthoquinones Derivatives in the Search of Anticancer Lead Compounds.

ABSTRACT: Naphthoquinones are a valuable source of secondary metabolites that are well known for their dye properties since ancient times. A wide range of biological activities have been described highlighting their cytotoxic activity, gaining the attention of researchers in recent years. In addition, it is also worth mentioning that many anticancer drugs possess a naphthoquinone backbone in their structure. Considering this background, the work described herein reports the evaluation of the cytotoxicity of different acyl and alkyl derivatives from juglone and lawsone that showed the best activity results from a etiolated wheat coleoptile bioassay. This bioassay is rapid, highly sensitive to a wide spectrum of activities, and is a powerful tool for detecting biologically active natural products. A p

SUBMITTER: Duran AG 

PROVIDER: S-EPMC10222971 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature