The Anti-Cancer Effect of Cinnamon Aqueous Extract: A Focus on Hematological Malignancies.

ABSTRACT: Cinnamon is an evergreen and tropical plant of the family Lauraceae, growing particularly in Sri Lanka, whose aqueous extract has been tested in different studies to evaluate its possible use as an anti-cancer compound. Both in vitro and in vivo experiments seem to confirm that it acts on various cellular pathways, contributing to down-regulating the activity of molecules that stimulate the proliferation and survival of cells such as the transcription factors NF-KB and AP-1, COX-2, dihydrofolate reductase and pro-angiogenic substances such as VEGF, while up-regulating the function of immune cells against tumors, such as cytotoxic CD8+ T cells. In hematological malignancies, aqueous cinnamon extract has been studied in order to understand if it is possible to count on its help, alone

SUBMITTER: Caserta S 

PROVIDER: S-EPMC10222973 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature