Toxicological Profile of PM from Different Sources in the Bronchial Epithelial Cell Line BEAS-2B.

ABSTRACT: The toxicity of particulate matter (PM) is strictly associated with its physical-chemical characteristics, such as size or chemical composition. While these properties depend on the origin of the particles, the study of the toxicological profile of PM from single sources has rarely been highlighted. Hence, the focus of this research was to investigate the biological effects of PM from five relevant sources of atmospheric PM: diesel exhaust particles, coke dust, pellet ashes, incinerator ashes, and brake dust. Cytotoxicity, genotoxicity, oxidative, and inflammatory response were assessed in a bronchial cell line (BEAS-2B). BEAS-2B cells were exposed to different concentrations (25, 50, 100, and 150 μg/mL medium) of particles suspended in water. The exposure lasted 24 h for all the assays pe

SUBMITTER: Melzi G 

PROVIDER: S-EPMC10222988 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature