Accelerated Production of Biopharmaceuticals via Microwave-Assisted Freeze-Drying (MFD).

ABSTRACT: Recently, attention has been drawn to microwave-assisted freeze-drying (MFD), as it drastically reduces the typically long drying times of biopharmaceuticals in conventional freeze-drying (CFD). Nevertheless, previously described prototype machines lack important attributes such as in-chamber freezing and stoppering, not allowing for the performance of representative vial freeze-drying processes. In this study, we present a new technical MFD setup, designed with GMP processes in mind. It is based on a standard lyophilizer equipped with flat semiconductor microwave modules. The idea was to enable the retrofitting of standard freeze-dryers with a microwave option, which would reduce the hurdles of implementation. We aimed to collect process data with respect to the speed, settings, and contr

SUBMITTER: Hardter N 

PROVIDER: S-EPMC10223035 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature