Dapagliflozin Ameliorates Cognitive Impairment in Aluminum-Chloride-Induced Alzheimer's Disease via Modulation of AMPK/mTOR, Oxidative Stress and Glucose Metabolism.

ABSTRACT: Alzheimer's disease (AD) is a progressive neurological illness characterized by memory loss and cognitive deterioration. Dapagliflozin was suggested to attenuate the memory impairment associated with AD; however, its mechanisms were not fully elucidated. This study aims to examine the possible mechanisms of the neuroprotective effects of dapagliflozin against aluminum chloride (AlCl₃)-induced AD. Rats were distributed into four groups: group 1 received saline, group 2 received AlCl₃ (70 mg/kg) daily for 9 weeks, and groups 3 and 4 were administered AlCl₃ (70 mg/kg) daily for 5 weeks. Dapagliflozin (1 mg/kg) and dapagliflozin (5 mg/kg) were then given daily with AlCl₃ for another 4 weeks. Two behavioral experiments were performed: the Morris Water

SUBMITTER: Samman WA 

PROVIDER: S-EPMC10223357 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature